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Proiect: MECANISMELE PERIFERICE ALE DURERII INFLAMATORII: ROLUL CANALELOR ACTIVATE DE TEMPERATURILE EXTREME, TRPA1 SI TRPV2

DIRECTOR DE PROIECT : PROF. DR. ALEXANDRU BABES

Publicatii rezultate


1. Articole în jurnale de specialitate cotate ISI:

1. Babes, A., Ciobanu, A. C., Neacsu, C., Babes, R. M. (2011), "TRPM8, a Sensor for Mild Cooling in Mammalian Sensory Nerve Endings", Current Pharmaceutical Biotechnology, 12(1): 78-88.

2. Neacsu, C., Babes, A. (2010), "The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1", Journal of Pharmacological Sciences, 114(3): 332-340.

3. Neacsu, C., Ciobanu, C., Barbu, I., Toader, O., Szegli, G., Kerek, F., Babes, A. (2010), “Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons”, Physiological Research, 59(2): 289-298.

4. Ciobanu, C., Reid, G., Babes, A. (2009), “Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons”, Brain Research, 1284:54-67.

2. Articole în jurnale indexate în baze de date internationale (BDI):

1. Babes, A. (2009), “Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms”, Biophysical Reviews, 1: 193-200.

3. Abstracte prezentate la conferinte internationale:

1. Ciobanu, C., Babes, A., Reid, G. (2010), "Structural determinants of transient receptor potential vanilloid subtype 1 (TRPV1) sensitivity to camphor", FENS Abstr. Vol 5, 020.3.

2. Babes, A., Neacsu, C., Sauer, S. K., Bierhaus, A., Nawroth, P. P., Reeh, P. (2010), "Prolonged exposure to methylglyoxal increases the excitability of cultured mouse dorsal root ganglion neurons", FENS Abstr. Vol 5, 020.2.

3. Neacsu, C., Babes, A. (2010), "The Kv7 potassium channel blocker linopirdine is an agonist of the polymodal receptor transient receptor potential vanilloid type 1 (TRPV1)", FENS Abstr. Vol 5, 020.14.

4. Barbu, I., Neacsu, C., Babes, A. (2008), “M-current inhibition by linopirdine sensitizes rat dorsal root ganglion neurons to heat”, FENS Abstr. Vol 4, 124.3;

5. Babes, A., Neacsu, C., Ciobanu, C., Toader, O., Barbu, I., Szegli, G., Kerek, F. (2008), “Substance MCS-18A from Helleborus purpurescens inhibits TRPV1 in rat dorsal root ganglion neurons”, FENS Abstr. Vol 4, 124.2;

6. Ciobanu, A.C., Babes, A. (2008), “GDNF increases the level of TRP channels co-expression in rat dorsal root ganglion (DRG) neurons”, FENS Abstr. Vol 4, 124.6;

7. Linte, R.M., Leffler, A., Nau, C., Reeh, P., Babes, A. (2008), “A vanilloid type transient receptor potential TRPV2-like heat-activated channel in rat dorsal root ganglion neurons”, FENS Abstr. Vol 4, 124.22;

8. Barbu, I.C., Babes, A. (2008), “Rat dorsal root ganglion (DRG) neurons expressing large M-curents are less excitable and have reduced capsaicin sensitivity”, Acta Physiologica, 192, supplement 663: 176 (online ISSN: 1784-1716);

9. Neacsu, C., Ciobanu, C., Toader, O., Szegli, G., Kerek, F., Babes, A. (2008), Substance MCS-18A from Helleborus purp. As potent antagonist of the polymodal receptor TRPV1”, Acta Physiologica, 192, supplement 663: 53 (online ISSN: 1784-1716);

10. Babes, A., Leffler, A., Linte, R., Nau, C., Reeh, P. (2007), “Evidence for functional expression of TRPV2 in rat DRG neurons”, Acta Physiologica, 191, supplement 658: 43 (online ISSN: 1784-1716);

11. Babes, A., Leffler, A., Linte, R., Nau, C., Reeh, P. (2007), “A high-threshold heat-activated channel in rat DRG resembles TRPV2”, Acta Physiologica, 189, supplement 653: 53 (online ISSN: 1784-1716).

 

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